HLA-DR1 (DRA, DRB1 0101) HUMAN CLASS II HISTOCOMPATIBILITY PROTEIN (EXTRACELLULAR DOMAIN) COMPLEXED WITH ENDOGENOUS PEPTIDE

The class II MHC protein HLA-DR1 in complex with an endogenous peptide: implications for the structural basis of the specificity of peptide binding.

Cambridge, Ma : Massachusetts Institute of Technology (Thesis)
Three Dimensional Structure of a Human Class II Mhc Protein Hla-Dr1 Bound to an Endogenous Peptide

Crystal Structure of the Human Class II Mhc Protein Hla-Dr1 Complexed with an Influenza Virus Peptide

Three-Dimensional Structure of the Human Class II Histocompatibility Antigen Hla-Dr1

HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN

HLA-DR1 IS A CLASS II MHC PROTEIN, HLA-A2 IS A CLASS I HISTOCOMPATIBILITY ANTIGEN

CRYSTALS GREW AS NEEDLES FROM 10MG/ML HLA-DR1 / PEPTIDE COMPLEX, 15% PEG 4000, 100MM GLYCINE, PH 3.5, AT ROOM TEMPERATURE, OVER ONE WEEK.

REFMAC USED IN LATER STAGES OF REFINEMENT.

HLA-DR1 CLASS II HISTOCOMPATIBILITY PROTEIN, HLA-A2

THERE ARE FOUR MOLECULES IN THIS COORDINATE SET EACH MOLECULE HAS ONE ALPHA CHAIN : RESIDUES 3-182 EACH MOLECULE HAS ONE BETA CHAIN : RESIDUES 4-190 EACH MOLECULE HAS ONE PEPTIDE CHAIN: RESIDUES 3-14

MOLECULE THREE IS THE MOST WELL DEFINED. MOLECULES 1 - 2 AND 3 - 4 EACH FORM THE SO-CALLED "DIMER OF DIMERS".

COMPLEX (MHC PROTEIN-ANTIGEN), HISTOCOMPATIBILITY ANTIGEN, COMPLEX (MHC PROTEIN-ANTIGEN) complex