The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Phosphatidylinositol 3-kinase regulatory subunit alpha

PtdIns-3-kinase subunit delta,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta,p110delta

PtdIns-3-kinase regulatory subunit alpha,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,PtdIns-3-kinase regulatory subunit p85-alpha

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (E.C.2.7.1.153), Phosphatidylinositol 3-kinase regulatory subunit alpha

lipid kinase, inhibitor, Transferase-Inhibitor complex