Crystal Structure of the Alpha-kinase Domain of Myosin-II Heavy Chain Kinase A in Complex with AMP-PNP

PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

Structure of the Dictyostelium Myosin-II Heavy Chain Kinase A (MHCK-A) alpha-kinase domain apoenzyme reveals a novel autoinhibited conformation.

alpha kinase domain (UNP residues 552-841)

20% PEG8000, 0.1 M MOPS, 0.2 M magnesium sulfate

Canadian Institutes of Health Research (CIHR)

Myosin-II Heavy Chain Kinase A complexed with AMP

Myosin-II Heavy Chain Kinase A complexed with AMP-PCP

Myosin-II Heavy Chain Kinase A complexed with ADP

Myosin-II Heavy Chain Kinase A D766A mutant complexed with ATP

Myosin-II Heavy Chain Kinase A with 32 amino acid C-terminal truncation

Myosin-II Heavy Chain Kinase A complexed with adenosine

Myosin-II Heavy Chain Kinase A with phosphorylated aspartate

Myosin-II Heavy Chain Kinase A D756A mutant complexed with ATP

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

Myosin-II heavy chain kinase A (E.C.2.7.11.7)

atypical Ser/Thr protein kinase, alpha kinase, TRANSFERASE