Crystal structure of PRMT5:MEP50 with Compound 8 and sinefungin

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666.

72 kDa ICln-binding protein,Histone-arginine N-methyltransferase PRMT5,Jak-binding protein 1,Shk1 kinase-binding protein 1 homolog,SKB1Hs

MEP-50,Androgen receptor cofactor p44,WD repeat-containing protein 77,p44/Mep50

0.2 M Sodium acetate, 0.1 M Sodium citrate pH 6.1, 10% w/v PEG 4000

HYDROGENS HAVE BEEN USED IF PRESENT IN THE INPUT U VALUES : REFINED INDIVIDUALLY

Protein arginine N-methyltransferase 5 (E.C.2.1.1.-,2.1.1.125), Methylosome protein 50

protein-inhibitor complex, TRANSFERASE-TRANSFERASE INHIBITOR complex