Crystal structure of the PI5P4Kbeta T201M-2a-ATP complex

[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(azanyl)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate

[[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(azanyl)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate

The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity.

Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1-phosphatidylinositol 5-phosphate 4-kinase 2-beta,Diphosphoinositide kinase 2-beta,Phosphatidylinositol 5-phosphate 4-kinase type II beta,PI(5)P 4-kinase type II beta,PIP4KII-beta,PtdIns(5)P-4-kinase isoform 2-beta

9%(w/v) PEG4000, 0.1M sodium citrate pH 6.0, 0.1M magnesium acetate, 0.1M lithium acetate

Japan Agency for Medical Research and Development (AMED)

Lipid Kinase, Phosphoinositide signaling, Transferase

(chain 'A' and ((resid 33 and (name N or name CA or name C or name O or name CB )) or resid 34 through 85 or (resid 86 and (name N or name CA or name C or name O or name CB )) or resid 87 through 93 or (resid 94 and (name N or name CA or name C or name O or name CB )) or resid 95 through 144 or (resid 145 and (name N or name CA or name C or name O or name CB )) or resid 146 through 161 or (resid 162 and (name N or name CA or name C or name O or name CB )) or resid 163 through 207 or (resid 208 and (name N or name CA or name C or name O or name CB )) or resid 209 through 210 or (resid 211 and (name N or name CA or name C or name O or name CB )) or resid 212 through 213 or (resid 214 through 215 and (name N or name CA or name C or name O or name CB )) or resid 216 through 234 or (resid 235 and (name N or name CA or name C or name O or name CB )) or resid 236 or (resid 237 through 241 and (name N or name CA or name C or name O or name CB )) or resid 242 or (resid 243 through 246 and (name N or name CA or name C or name O or name CB )) or resid 247 through 249 or (resid 250 through 252 and (name N or name CA or name C or name O or name CB )) or resid 253 or (resid 254 through 258 and (name N or name CA or name C or name O or name CB )) or resid 259 through 260 or (resid 261 through 266 and (name N or name CA or name C or name O or name CB )) or resid 267 through 268 or (resid 269 and (name N or name CA or name C or name O or name CB )) or resid 270 through 275 or (resid 276 through 278 and (name N or name CA or name C or name O or name CB )) or resid 279 through 284 or (resid 285 and (name N or name CA or name C or name O or name CB )) or resid 286 through 287 or (resid 288 through 289 and (name N or name CA or name C or name O or name CB )) or resid 290 through 293 or resid 338 through 352 or (resid 353 and (name N or name CA or name C or name O or name CB )) or resid 354 through 355 or (resid 356 through 357 and (name N or name CA or name C or name O or name CB )) or resid 358 through 368 or (resid 369 and (name N or name CA or name C or name O or name CB )) or resid 370 through 372 or resid 400 through 403 or (resid 404 through 406 and (name N or name CA or name C or name O or name CB )) or resid 407 or (resid 408 through 409 and (name N or name CA or name C or name O or name CB )) or resid 410 through 412 or (resid 413 and (name N or name CA or name C or name O or name CB )) or resid 414 or (resid 415 and (name N or name CA or name C or name O or name CB ))))

(chain 'B' and (resid 33 through 64 or (resid 65 and (name N or name CA or name C or name O or name CB )) or resid 66 through 71 or (resid 72 through 73 and (name N or name CA or name C or name O or name CB )) or resid 74 through 75 or (resid 76 and (name N or name CA or name C or name O or name CB )) or resid 77 through 154 or (resid 155 and (name N or name CA or name C or name O or name CB )) or resid 156 through 172 or (resid 173 and (name N or name CA or name C or name O or name CB )) or resid 174 through 233 or (resid 234 through 235 and (name N or name CA or name C or name O or name CB )) or resid 236 through 293 or resid 338 through 340 or (resid 341 and (name N or name CA or name C or name O or name CB )) or resid 342 through 344 or (resid 345 and (name N or name CA or name C or name O or name CB )) or resid 346 through 371 or (resid 372 and (name N or name CA or name C or name O or name CB )) or resid 400 through 405 or (resid 406 and (name N or name CA or name C or name O or name CB )) or resid 407 through 415))