Cryo-EM structure of afamelanotide-bound melanocortin-1 receptor in complex with Gs protein and scFv16

Structural mechanism of calcium-mediated hormone recognition and G beta interaction by the human melanocortin-1 receptor.

Guanine nucleotide-binding protein G(i) subunit alpha-1

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Ministry of Science and Technology (MoST, China)

G protein-coupled receptors, MC1R, melanocyte, clacium ion, activation, MEMBRANE PROTEIN