Crystal structure of SARS coronavirus main peptidase at pH 6.0 in the space group P21

Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase.

2% PEG 20000, 3% dimethyl sulfoxide, 1mM dithiothreitol, 0.1 M MES (pH 6.0), VAPOR DIFFUSION, HANGING DROP, temperature 298K

cysteine peptidase, 3C-like, N-finger, chymotrypsin-like fold, long loop, alpha-helical domain, dimer, catalytic dyad, specificity pockets, HYDROLASE