Crystal structure of human Arginase-2 complexed with inhibitor 9

Discovery of (R)-2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury.

Kidney-type arginase, Non-hepatic arginase, Type II arginase

Crystals in condition H3 from Silver Bullet screen (Hampton Research) using Tacsimate in the reservoir, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 277K

biological assembly is a homotrimer with one copy in the asymmetric unit

metalloenzyme, alpha/beta fold, Hydrolase, Arginine metabolism, Manganese, Mitochondrion, Hydrolase-Hydrolase Inhibitor complex