Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 34

2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.

Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion.

S-adenosylmethionine synthase isoform type-2

AdoMet synthase 2,Methionine adenosyltransferase 2,MAT 2,Methionine adenosyltransferase II,MAT-II

0.2 M Lithium Chloride, 0.1 M Tris PH 7.8, 20% PEG 6000, 10% Ethylene Glycol

7KCC contains the same protein complexed with compound AG-270

7KCE contains the same protein complexed with compound 2

7KCF contains the same protein complexed with compound 24512

S-adenosylmethionine synthase isoform type-2 (E.C.2.5.1.6)

METHIONINE ADENOSYLTRANSFERASE, SAM, Allosteric Inhibitor, TRANSFERASE, TRANSFERASE-Inhibitor complex