Structural basis for a germline-biased antibody response to SARS-CoV-2 (RBD:C1A-C2 Fab)

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2.

heavy chain of human antibody C1A-C2 Fab

light chain of human antibody C1A-C2 Fab

Severe acute respiratory syndrome coronavirus 2

protein sample: 13 mg/mL in 150mM NaCl, 25 mM Tris-HCl pH 7.5

mother liquor composition (equal volume): 0.03 M Citric acid, 0.07M BIS-TRIS propane/pH 7.6, 20% (w/v) PEG 3350

Spike glycoprotein, heavy chain of human antibody C1A-C2 Fab, light chain of human antibody C1A-C2 Fab

COVID-19, SARS-CoV-2, neutralizing antibody, affinity maturation, IMMUNE SYSTEM, IMMUNE SYSTEM-Viral protein complex