Complex of high-affinity SIRP alpha variant FD6 with CD47

Engineered SIRP alpha variants as immunotherapeutic adjuvants to anticancer antibodies.

Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Protein MER6

Crystals were obtained by addition of 0.1 microL protein to an equal volume of 2.0 M ammonium sulfate and 0.1 M Tris, pH 7.3, VAPOR DIFFUSION, SITTING DROP, temperature 295K

AUTHORS STATE THAT THIS RESIDUE IS ENCODED AS GLUTAMINE, BUT SPONTANEOUSLY CYCLIZES TO PYROGLUTAMIC ACID.

Leukocyte surface antigen CD47, High-affinity SIRPa variant FD6

Immunoglobulin fold, Immune regulation, N-linked glycosylation, Plasma membrane, IMMUNE SYSTEM