Crystal Structure of the Complex of PDZ-RhoGEF DH/PH domains with GTP-gamma-S Activated RhoA

Activated RhoA binds to the pleckstrin homology (PH) domain of PDZ-RhoGEF, a potential site for autoregulation.

Rosenbaum-Rock double-crystal monochromator

Rho guanine nucleotide exchange factor 11

14-16% PEG 10000, 0.1M ammonium acetate, 0.1M Bis-Tris, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K

The same DH/PH domains complexed with nucleotide-free RhoA.

A family member of RhoGEF DH/PH domains complexed with nucleotide-free RhoA.

A family member of RhoGEF DH/PH domains.

B-factors reported represent the sum of TLS and residual B-factors

Rho guanine nucleotide exchange factor 11, Transforming protein RhoA

regulation of RhoA GTPase, RhoGEF, DH, PH, Rho, GTPase activation, Guanine-nucleotide releasing factor, Membrane, Cytoskeleton, GTP-binding, Magnesium, Nucleotide-binding, Prenylation, Proto-oncogene, signaling protein