Crystal structure of the large fragment of DNA polymerase I from Thermus aquaticus in a closed ternary complex with trapped 4'-methylated dTTP

4'-methylthymidine 5'-(tetrahydrogen triphosphate)

Structures of DNA polymerases caught processing size-augmented nucleotide probes.

This noise-free counting device combines extraordinary spatial resolution with full frame read-out times of 5 ms. These features make it an ideal detector for PX and enable novel data acquisition modes such as continuos data acquisition and fine-phi-slicing.

LN2 cooled fixed-exit. Si(111) monochromator

DNA (5'-D(*GP*AP*CP*CP*AP*CP*GP*GP*CP*GP*CP*(DOC))-3')

DNA (5'-D(*AP*AP*AP*AP*GP*GP*CP*GP*CP*CP*GP*TP*GP*GP*TP*C)-3')

30% (w/v) PEG 8000, 0.2M ammonium acetate, 0.02M magnesium acetate, 0.05M sodium cacodylate, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K

DNA polymerase I, thermostable (E.C.2.7.7.7)

DNA, DNA polymerase, DNA replication, nucleotides, modified nucleotide, artificial nucleotide, nucleotide probes, DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase, Transferase-DNA complex