Structure of Pyroglutamate-Abeta-specific Fab c#24 in complex with human Abeta-pE3-18

Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy.

Pyroglutamate residue 1 (PCA) results from post-translational modification of original residue glutamine 1.

20% w/v PEG 3000
100 mM sodium citrate pH 5.5

Fab c#17 light chain, Fab c#17 heavy chain, Pyroglutamate-Abeta pE3-12-PEGb

Alzheimer's disease, pyroglutamate Abeta, monoclonal antibody, fibrillation, IMMUNE SYSTEM