Crystal structure of 3945 Fab in complex with circumsporozoite protein NANP3 and anti-Kappa VHH domain

Evolution of protective human antibodies against Plasmodium falciparum circumsporozoite protein repeat motifs.

0.2 M di-sodium hydrogen phosphate, 20 % (w/v) PEG 3350

3945 Fab heavy chain, 3945 Kappa light chain, Anti-Kappa VHH domain, Circumsporozoite protein

(chain A and ((resid 1 and (name N or name CA or name C or name O or name CB )) or resid 2 through 15 or (resid 16 and (name N or name CA or name C or name O or name CB )) or resid 17 through 127 or resid 133 through 200 or (resid 201 and (name N or name CA or name C or name O or name CB )) or resid 202 through 205 or (resid 206 and (name N or name CA or name C or name O or name CB )) or resid 207 through 209 or (resid 210 and (name N or name CA or name C or name O or name CB )) or resid 211 through 213))

(chain E and (resid 1 through 74 or (resid 75 and (name N or name CA or name C or name O or name CB )) or resid 76 through 200 or (resid 201 and (name N or name CA or name C or name O or name CB )) or resid 202 through 213))

(chain I and ((resid 1 and (name N or name CA or name C or name O or name CB )) or resid 2 through 15 or (resid 16 and (name N or name CA or name C or name O or name CB )) or resid 17 through 74 or (resid 75 and (name N or name CA or name C or name O or name CB )) or resid 76 through 127 or resid 133 through 205 or (resid 206 and (name N or name CA or name C or name O or name CB )) or resid 207 through 213))

(chain B and (resid 1 through 76 or (resid 77 and (name N or name CA or name C or name O or name CB )) or resid 78 through 125 or (resid 126 and (name N or name CA or name C or name O or name CB )) or resid 127 through 168 or (resid 169 and (name N or name CA or name C or name O or name CB )) or resid 170 through 212))

(chain F and (resid 1 through 76 or (resid 77 and (name N or name CA or name C or name O or name CB )) or resid 78 through 168 or (resid 169 and (name N or name CA or name C or name O or name CB )) or resid 170 through 212))

(chain J and (resid 1 through 125 or (resid 126 and (name N or name CA or name C or name O or name CB )) or resid 127 through 212))