CRYSTAL STRUCTURE OF THE BETA-LACTAMASE OXA-245

Structure, activity and thermostability investigations of OXA-163, OXA-181 and OXA-245 using biochemical analysis, crystal structures and differential scanning calorimetry analysis.

The homolog OXA-48 was shown to be dimeric by SEC. Our DSC results with OXA-48 and OXA-245 indicate that OXA-245 is also a dimer.

antibiotic resistance, oxacillinase, OXA-48-like, carbapenemase, ANTIBIOTIC