The crystal structure of CK2alpha in complex with compound 2

Second-generation CK2 alpha inhibitors targeting the alpha D pocket.

residues 2-329 and N-terminal extension GSMDIEFDDDADDDGSGSGSGSGS

112.5mM Mes pH 6.5, 35% glycerol ethoxylate, 180 mM ammonium acetate

Casein kinase II subunit alpha (E.C.2.7.11.1)

CK2alpha, CK2a, fragment based drug discovery, high concentration screening, selective ATP competitive inhibitors, surface entrophy reduction, transferase