Dihydropteroate Synthetase, With Bound Inhibitor MANIC, From Bacillus anthracis

Crystal Structure of 7,8-Dihydropteroate Synthase from Bacillus anthracis; Mechanism and Novel Inhibitor Design.

lithium sulfate, tris, pH 9, VAPOR DIFFUSION, HANGING DROP, temperature 291K

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. TLS REFINEMENT USED THROUGHOUT

DHPS, Dihydropteroate synthase (E.C.2.5.1.15)

The biological dimer is generated
by the two fold axis: x,y,z

anthracis, folate biosynthesis, dihydropteroate, pterine, MANIC, Transferase