Structure of rat neuronal nitric oxide synthase heme domain in complex with N1-(3-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)-5- fluorophenyl)-N1,N2-dimethylethane-1,2-diamine

2-Aminopyridines with a Truncated Side Chain to Improve Human Neuronal Nitric Oxide Synthase Inhibitory Potency and Selectivity.

BNOS, CONSTITUTIVE NOS, NC-NOS, NOS TYPE I, NEURONAL NOS, N -NOS, NNOS, PEPTIDYL-CYSTEINE S-NITROSYLASE NOS1, NEURONAL NITRIC OXIDE SYNTHASE

20-22% PEG3350 0.1M MES, PH5.8 140-200 MM AMMONIUM ACETATE 10% ETHYLENE GLYCOL 5 MM GSH 30UM SDS

STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH N1-(3-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PHENYL)-N1,N2-DIMETHYLETHANE- 1,2-DIAMINE

STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH N1-(6-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-2-YL)-N1,N2- DIMETHYLETHANE-1,2-DIAMINE

STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH N1-(5-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)-N1,N2- DIMETHYLETHANE-1,2-DIAMINE

STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH N1-(3-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)-5-(TRIFLUOROMETHYL)PHENYL)-N1 ,N2-DIMETHYLETHANE-1,2-DIAMINE

STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 3-(2-(6-AMINO-4-METHYLPYRIDIN -2-YL)ETHYL)-5-(METHYL(2-(METHYLAMINO)ETHYL)AMINO) BENZONITRILE

STRUCTURE OF HUMAN NNOS R354A G357D MUTANT HEME DOMAIN IN COMPLEX WITH N1-(5-(2-(6-AMINO-4-METHYLPYRIDIN -2-YL)ETHYL)PYRIDIN-3-YL)-N1,N2-DIMETHYLETHANE-1, 2-DIAMINE

STRUCTURE OF HUMAN NNOS R354A G357D MUTANT HEME DOMAIN IN COMPLEX WITH 3-(2-(6-AMINO-4-METHYLPYRIDIN-2- YL)ETHYL)-5-(METHYL(2-(METHYLAMINO)ETHYL)AMINO) BENZONITRILE

STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH N1-(3-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PHENYL)-N1,N2-DIMETHYLETHANE- 1,2-DIAMINE

STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH N1-(5-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)PYRIDIN-3-YL)-N1,N2- DIMETHYLETHANE-1,2-DIAMINE

STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH N1-(3-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)-5-FLUOROPHENYL)-N1,N2- DIMETHYLETHANE-1,2-DIAMINE

STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 3-(2-(6-AMINO-4- METHYLPYRIDIN-2-YL)ETHYL)-5-(METHYL(2-(METHYLAMINO) ETHYL)AMINO)BENZONITRILE

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. U VALUES WITH TLS ADDED. RESIDUES 339 TO 349 IN CHAIN A AND 339 TO 347 IN CHAIN B ARE DISORDERED.

NITRIC OXIDE SYNTHASE, BRAIN (E.C.1.14.13.39)

OXIDOREDUCTASE, NITRIC OXIDE SYNTHASE, INHIBITOR COMPLEX