Crystal structure of IRE1a in complex with compound 18

Disruption of IRE1 alpha through its kinase domain attenuates multiple myeloma.

Serine/threonine-protein kinase/endoribonuclease IRE1

Endoplasmic reticulum-to-nucleus signaling 1,Inositol-requiring protein 1,hIRE1p,Ire1-alpha,IRE1a

0.1M trisodium citrate pH 5.6, 10% isopropanol, 10% PEG4000, and cesium chloride

Serine/threonine-protein kinase/endoribonuclease IRE1 (E.C.2.7.11.1,3.1.26.-)

Kinase, RNase, inhibitor, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex