Cryo-EM structure of the SARS-CoV-2 spike protein (2-up RBD) bound to neutralizing nanobodies P86

alpha-L-fucose; 6-deoxy-alpha-L-galactopyranose; L-fucose; fucose

N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE

A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron.

SARS-CoV-2 spike protein (2-up RBD) bound to neutralizing nanobodies P86

Severe acute respiratory syndrome coronavirus 2

The graphene grid was chemically oxidized and modified.

Japan Agency for Medical Research and Development (AMED)

Japan Society for the Promotion of Science (JSPS)

spike, nanobody, VHH, VIRAL PROTEIN, VIRAL PROTEIN-IMMUNE SYSTEM complex