Evolutionary basis of HIV restriction by the antiretroviral TRIMCyp

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity.

0.33 mM each of Mafa Cyp and HIV-1 CAN in 20 mM HEPES pH 7, 50 mM NaCl, 1 mM DTT was mixed with reservoir solution (30% PEG 6000, 1 M LiCl, 0.1 M HEPES pH 7, 0.5% ethyl acetate

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

TRIM, VIRAL PROTEIN, RESTRICTION FACTOR IMMUNITY