Full-length Hsc82 in complex with Aha1 in the presence of AMP-PNP

PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

82 kDa heat shock cognate protein,Heat shock protein Hsp90 constitutive isoform

National Institutes of Health/National Cancer Institute (NIH/NCI)

National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)

ATP-dependent molecular chaperone HSC82, Hsp90 co-chaperone AHA1