Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.

cAMP-specific 3',5'-cyclic phosphodiesterase 4D
CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D

PEG3350, ethylene glycol, isopropanol, glycerol and DTT , pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 288K

HETEROGEN
HOH 1003-1008 ARE ASSOCIATED WITH CHAIN A.
HOH 2003-2008 ARE ASSOCIATED WITH CHAIN B.

HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS

cAMP-specific 3',5'-cyclic phosphodiesterase 4D (E.C.3.1.4.17)

Phosphodiesterase, PDE, PDE4D, Roflumilast, HYDROLASE